Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers

• DOI: 10.1021/acs.jafc.0c05417
• Publication Date: 2021-01-13T23:53:00Z
• Authors: Xin Zhou; Wenjun Xu; Yiran Li; Meihui Zhang; Pengfei Tang; Weijia Lu; Qiji Li; Hao Zhang; Jun Luo; Lingyi Kong
• Keywords: Nonalcoholic steatohepatitis; Hypericum

In this work, 26 methylated acylphloroglucinol meroterpenoids with diverse skeletons, including 18 new ones (bellumones A-R, 1–18), were identified from the flowers of Hypericum bellum. Their structures absolute configurations elucidated by detailed spectroscopic data, calculated electronic circular dichroism (ECD), and X-ray diffraction (XRD). Through methylation at C-5, prenylation different chain lengths acylphloroglucinol-derived core, along types secondary cyclization, type A bicyclic polyprenylated acylphloroglucinols (BPAPs) (1–5 19–24) dearomatized isoprenylated (DIAPs) (6–18 25–26) obtained. The significant results anti-inflammatory, antioxidant, anti-nonalcoholic steatohepatitis (anti-NASH) activities suggest its usefulness in daily health care.