Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice

• DOI: 10.1021/acs.jafc.0c05899
• Publication Date: 2020-12-09T16:59:17Z
• Authors: Zhijie Yao; Yongheng Yan; Xu Zheng; Mingfu Wang; Hao Zhang; Haitao Li; Wei Chen
• Keywords: Browning

Yogurt has been widely used in weight-loss foods to prevent obesity, but its molecular nature remains unclear. Lactate is a major ingredient of yogurt, while cognate cell surface receptor GPR81 highly expressed adipose tissues mammals. Here we hypothesized that dietary lactate supplementation might activate promote browning. Studying mouse models, observed was substantially lowered tissue obese mice compared with for lean ones, whereas expression markedly up-regulated by β3-adrenergic (β3-AR) agonist. The deficiency greatly attenuated experimental browning and thermogenesis. Importantly, oral administration effectively induced browning, enhanced thermogenesis, improved dyslipidemia, protected against high-fat-diet-induced obesity. Mechanistically, p38 mitogen-activated protein kinase serve as key downstream effect or GPR81. Collectively, our findings revealed critical role provided new insight into obesity management modulating lactate-GPR81 signaling axis.