Xylooligosaccharides Increase Bifidobacteria and Lachnospiraceae in Mice on a High-Fat Diet, with a Concomitant Increase in Short-Chain Fatty Acids, Especially Butyric Acid

• DOI: 10.1021/acs.jafc.0c06279
• Publication Date: 2021-03-16T14:36:20Z
• Authors: Karin Berger; Stephen Burleigh; Maria Lindahl; Abhishek Bhattach...; Prachiti Patil; Henrik Stålbrand; Eva Nordberg Karl...; Frida Hållenius; Margareta Nyman; Patrick Adlercreutz
• Keywords: Lachnospiraceae; Prebiotic; Cecum; Short-chain fatty acid; Guar gum

Effects of xylooligosaccharides (XOSs) as well a mixture XOS, inulin, oligofructose, and partially hydrolyzed guar gum (MIX) in mice fed high-fat diet (HFD) were studied. Control groups an HFD or low-fat diet. Special attention was paid to the cecal composition gut microbiota formation short-chain fatty acids, but metabolic parameters also documented. The XOS group had significantly higher cecum levels acetic, propionic, butyric acids than group, acid content MIX group. contained more Bifidobacteria, Lachnospiraceae, S24-7 bacteria A tendency lower body weight gain observed on comparing groups. In conclusion, shown be promising prebiotic candidate. fiber diversity did not provide any advantages compared