Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function

• DOI: 10.1021/acs.jafc.1c02095
• Publication Date: 2021-08-02T15:51:53Z
• Authors: Jeffry S. Tang; Alissa Cait; Yanyan Li; Helena Abolins-Th...; Katie Gell; Patries M. Herst; David O’Sullivan; Olivier Gasser
• Keywords: 0303 health sciences; 03 medical and health sciences; Receptors, Aryl Hydrocarbon; Immunity; Tryptophan; Humans; Polyphenols; Ligands; 3. Good health

The ligand-activated aryl hydrocarbon receptor (AhR) is an important molecular regulator of immune function, whose activity can be modulated by dietary glucosinolate- and tryptophan-derived metabolites. In contrast, the potential use polyphenols as regulators AhR-dependent immunity remains unclear. this perspective, we discuss how cellular metabolism may alter net effect on AhR, thus potentially reconciling some conflicting observations reported in literature. We further provide a methodological roadmap, across fields immunology, metabolomics, gut microbial ecology, to explore effects polyphenol-rich diets AhR-regulated function humans.