Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor

• DOI: 10.1021/acs.jafc.1c05250
• Publication Date: 2021-10-21T00:57:02Z
• Authors: Mu-Zi Li; Yi Zhao; Hao-Ran Wang; Milton Talukder; Jin-Long Li
• Keywords: Nephrotoxicity; Blood urea nitrogen; CYP1B1

Di (2-ethylhexyl) phthalate (DEHP) is an environmentally persistent and bioaccumulative plasticizer. Accumulation of DEHP in the body can eventually cause kidney damage. As a type natural carotenoid, lycopene (LYC) has potential protective effect on renal cells, but mechanism not yet been elucidated. The major goal this study was to see how effective LYC at treating DEHP-induced nephrotoxicity mice. ICR mice were treated with (500 mg/kg BW/day or 1000 BW/day) (5 for 28 days. Through histopathology ultrastructure, we found that attenuated tubular cell glomerular relieved injury evidenced by lower levels blood urea nitrogen (Bun), creatinine (Cre), uric acid (Uric). Meanwhile, reduced expression molecule-1 (Kim-1) also supported it. Notably, alleviate activity content cytochrome P450 system (CYP450s) interfered DEHP. In addition, treatment nuclear accumulation aromatic hydrocarbon receptor (AhR) AhR transporter (Arnt), its downstream target genes such as P450-dependent monooxygenase (CYP) 1A1, 1A2, 1B1 significantly decreased normal group. summary, mediate AhR/Arnt signaling prevent toxicity caused exposure.