Ginsenoside Rg2 Ameliorating CDAHFD-Induced Hepatic Fibrosis by Regulating AKT/mTOR-Mediated Autophagy

• DOI: 10.1021/acs.jafc.1c07578
• Publication Date: 2022-02-01T17:08:00Z
• Authors: Ziwei He; Siyu Chen; Tingting Pan; Ao Li; Kangyu Wang; Zhuofeng Lin; Wei Liu; Yi Wang; Yanfang Wang
• Keywords: Hepatic stellate cell

Ginsenoside Rg2 (G-Rg2) in the rhizome of Panax ginseng can modify lipid accumulation, oxidative stress, and apoptosis liver induced by a high-fat diet. This research adds to this assessing potential antifibrosis effect G-Rg2 (including possible mechanisms). significantly improved pathological changes tissue choline-deficient, l-amino acid-defined, diet (CDAHFD), it inhibited serum transaminase, plasma lipopolysaccharide, hydroxyproline levels; TGF-β1, α-SMA, COL1A1 expression, activated AKT/mTOR signal pathway, expression autophagy-related proteins. The vitro experiments showed that also restored autophagy flux impairment oleic acid TGF-β1 promoting p62 degradation hepatocytes. In hepatic stellate (HSC-T6) cells, reversed lipopolysaccharide-induced activation through signaling inhibiting autophagy. Thus, ameliorates CDAHFD-induced fibrosis HSC-T6 cell AKT/mTOR-mediated