1,3,4-Oxadiazole Derivatives as Plant Activators for Controlling Plant Viral Diseases: Preparation and Assessment of the Effect of Auxiliaries

• DOI: 10.1021/acs.jafc.2c01988
• Publication Date: 2022-06-22T18:14:01Z
• Authors: Jin Ji; Wu-Bin Shao; Pan-Long Chu; Hong-Mei Xiang; Pu-Ying Qi; Xiang Zhou; Pei-Yi Wang; Song Yang
• Keywords: Moiety; EC50; Oxadiazole; Agrochemical

Plant viral diseases cause the loss of millions dollars to agriculture around world annually. Therefore, development highly efficient, ultra-low-dosage agrochemicals is desirable for protecting health crops and ensuring food security. Herein, a series 1,3,4-oxadiazole derivatives bearing an isopropanol amine moiety was prepared, inhibitory activity against tobacco mosaic virus (TMV) assessed. Notably, compound A14 exhibited excellent anti-TMV protective with EC50 value 137.7 mg L-1, which superior that ribavirin (590.0 L-1) ningnanmycin (248.2 L-1). Moreover, some compounds could be further enhanced (by up 5-30%) through supplementation 0.1% auxiliaries. Biochemical assays suggested suppress biosynthesis TMV induce plant's defense response. Given these merits, designed had outstanding bioactivities unusual action mechanisms were promising candidates controlling plant diseases.