Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism

• DOI: 10.1021/acs.jafc.2c06417
• Publication Date: 2022-11-15T16:34:22Z
• Authors: Xiaoxia Liu; Yunhui Zhang; Wanhua Li; Bowei Zhang; Jia Yin; Sijing Liuqi; Jin Wang; Bo Peng; Shuo Wang
• Keywords: Fucoidan; Deoxycholic acid; Lithocholic acid; Chenodeoxycholic acid; Taurocholic acid; Ursodeoxycholic acid; Lachnospiraceae

Gut dysbiosis and bile acid (BA) metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate effect fucoidan on BA gut microbiota dextran sulfate sodium-induced colitis mice. Our results showed that effectively suppressed colonic inflammation repaired barrier. In addition, increased relative abundance Lachnospiraceae family, such as Turicibacter, Muribaculum, Parasutterella, Colidextribacter, followed by an increase short-chain fatty acids, especially butyrate. Moreover, modulated elevating cholic acid, ursodeoxycholic deoxycholic lithocholic decreasing β-muricholic which led activation FXR TGR5 further enhanced barrier inflammation. revealed alleviating was largely mediated microbiota, confirmed fecal transplantation experiment. Collectively, these findings provided basis for a potential functional food