2-Hydroxychalcone as a Novel Natural Photosynthesis Inhibitor against Bloom-Forming Cyanobacteria

• DOI: 10.1021/acs.jafc.2c06665
• Publication Date: 2022-11-29T12:24:51Z
• Authors: Xin Zhang; Xu Yang; Yichen Huang; Jinlu Hu; Diao Wu; Niu Yang; Haiying Wang
• Keywords: Plastoquinone; Marchantia polymorpha

The control of harmful cyanobacterial blooms has been becoming a global challenge. development eco-friendly algicides with strong specificity is urgently needed. photosynthetic apparatus promising target site for to minimize the possible effects on animals and humans. In this study, biologically derived 2-hydroxychalcone efficiently inhibited growth bloom-forming M. aeruginosa by selectively interfering photosynthesis. 2-Hydroxychalcone targeting Photosystem II (PSII) electron transfer between primary secondary acceptors (QA QB) binding plastoquinone (PQ) molecules QB pocket at acceptor side PSII, as revealed polyphasic chlorophyll (Chl) fluorescence induction QA- reoxidation kinetics. Molecular docking D1 protein proteomic responses suggested that formed stable monodentate ligand nonheme iron in protein, provoking significant modulation PSII proteins. unique mode differentiated it from classical inhibitors. Furthermore, down-regulated expression microcystin (MC) synthesis-related genes restrain MC synthesis release. These results indicated potential application an algicide or template scaffold designing novel derivatives superior algicidal activity.