Glutamine Ameliorates Liver Steatosis via Regulation of Glycolipid Metabolism and Gut Microbiota in High-Fat Diet-Induced Obese Mice

• DOI: 10.1021/acs.jafc.3c05566
• Publication Date: 2023-10-17T13:08:15Z
• Authors: Xinbo Zhou; Junjie Zhang; Yutong Sun; Jian Shen; Bo Sun; Qingquan Ma
• Keywords: Steatosis; FOXO1; Sirtuin 1

Obesity and its associated conditions, such as nonalcoholic fatty liver disease (NAFLD), are risk factors for health. The aim of this study was to explore the effects glutamine (Gln) on steatosis induced by a high-fat diet (HFD) HEPG2 cells oleic acid. Gln demonstrated positive influence hepatic homeostasis suppressing acetyl CoA carboxylase (ACC) acid synthase (FAS) promoting sirtuin 1 (SIRT1) expression while improving glucose metabolism regulating serine/threonine protein kinase (AKT)/factor forkhead box O1 (FOXO1) signals in vivo vitro. Obese Gln-fed mice had higher colonic short-chain (SCFA) contents lower inflammation factor levels liver, cells, jejunum. Gln-treated obese an effective decrease Firmicutes abundance. These findings indicate that serves nutritional tool managing obesity related disorders.