Bifidobacterium animalis subsp. lactis F1–7 Alleviates Lipid Accumulation in Atherosclerotic Mice via Modulating Bile Acid Metabolites to Downregulate Intestinal FXR

• DOI: 10.1021/acs.jafc.3c05709
• Publication Date: 2024-01-29T17:03:00Z
• Authors: Xi Liang; Xiumei Zheng; Peng Wang; Huaqi Zhang; Yiqing Ma; Hui Liang; Zhe Zhang
• Keywords: Bifidobacterium animalis; Farnesoid X receptor; Glycocholic acid; Lithocholic acid

The dysfunction of intestinal microbiota and bile acid metabolism is related to the pathogenesis atherosclerosis. This study we explored mechanism Bifidobacterium animalis subsp. lactis F1–7 (Bif. F1–7), improving atherosclerosis by regulating in ApoE–/– mice. Bif. effectively reduced aortic plaque accumulation improved serum liver lipid levels atherosclerotic untargeted metabolomics revealed that glycine-conjugated acids differential metabolite lithocholic (LCA) significantly. Downregulation LCA decreased farnesoid X-activated receptor (FXR) regulated through FXR/FGF15/CYP7A1 pathway. Furthermore, 16srRNA gene sequencing analysis structural changes with an increase abundance Bifidobacterium, Lactobacillus, Faecalibaculum, Desulfovibrio, a decrease Dubosiella, Clostridium_sensu_stricto_1, Turicibacter following intervention. Correlation showed mentioned above were significantly correlated In conclusion, this sheds light on mechanisms which regulates