Naturally Occurring Asterric Acid Analogs: Chemistry and Biology

• DOI: 10.1021/acs.jafc.3c06690
• Publication Date: 2024-02-22T20:41:20Z
• Authors: Yue Tan; Lin Chen; Gang Ding
• Keywords: Magnetic Resonance Spectroscopy; Phenyl Ethers; Biology

Asterric acid and its analogs belong to diphenyl ethers (DPEs) with multiple substitutions on A/B aromatic rings. This member of DPEs originates from the polyketide pathway displays a wide range biological effects. Though structures asterric are not complex, there were only more than 50 found in nature 1960 2023. In this review, structures, bioactivities, biosynthesis summarized. More importantly, empirical rule about shielding effect B-ring H-6 is suggested, provides convenient useful way analyze NMR spectral data analogs, based which chemical shift values A-ring some revised.