Exploring Anticancer Properties of Medicinal Plants against Breast Cancer by Downregulating Human Epidermal Growth Factor Receptor 2

• DOI: 10.1021/acs.jafc.3c07565
• Publication Date: 2024-04-16T15:42:59Z
• Authors: Sunny Gupta; Rashima Prem; Chinmayee Sethy; Saurabh Shrivastava; Manju Singh; Pramod Yadav; VG Huddar; PK Prajapati; Anita Roy; Monica Sundd; Ashok Kumar Patel
• Keywords: Terminalia chebula

Plants have a history of being employed in managing breast cancer. However, no scientific evidence supports the idea that these plants can effectively reduce level HER2 expression. In this study, extracts from 10 medicinal were evaluated for their anticancer properties against HER2-positive cancer cells through various methods, including SRB assay, comet annexin V-FITC dual staining, and immunoblotting. All exerted antiproliferative activity cells. Furthermore,