Milk-Derived Extracellular Vesicles: Biomedical Applications, Current Challenges, and Future Perspectives

• DOI: 10.1021/acs.jafc.3c07899
• Publication Date: 2024-04-08T16:00:02Z
• Authors: Mahsa Salehi; Babak Negahdari; Fatemeh Mehryab; Faezeh Shekari
• Keywords: Extracellular Vesicles; Isolation; Biomedicine

Extracellular vesicles (EVs) are nano to-micrometer-sized sacs that released by almost all animal and plant cells act as intercellular communicators transferring their cargos between the source target cells. As a safe scalable alternative to conditioned medium-derived EVs, milk-derived EVs (miEVs) have recently gained great deal of popularity. Numerous studies shown miEVs intrinsic therapeutic actions can treat diseases enhance human health. Additionally, they be used natural drug carriers novel classes biomarkers. However, due complexity milk, successful translation from benchtop bedside still faces several unfilled gaps, especially lack standardized protocols for isolation high-purity miEVs. In this work, comprehensively reviewing bovine studies, we provide an overview current knowledge research on while highlighting challenges enormous promise class theranostics. It is hoped study will pave way clinical applications addressing opportunities.