Fatty Acid Desaturase Bmdesat5, Suppressed in the Salivary Glands by Domestication, is Involved in Regulation of Food Intake in Silkworms

• DOI: 10.1021/acs.jafc.4c02511
• Publication Date: 2024-06-14T21:19:46Z
• Authors: Bingchuan Bai; Yuchan Wen; Jing Wang; Feng Wen; Hao Yan; Xingli Yuan; Jiatong Xie; Ruihan Zhang; Qingyou Xia; Genhong Wang
• Keywords: Vaccenic acid

Understanding the evolutionary genetics of food intake regulation in domesticated animals has relevance to biology, animal improvement, and obesity treatment. Here, we observed that fatty acid desaturase gene (Bmdesat5), which regulates intake, is suppressed silkworms, but expressed salivary glands wild silkworm Bombyx mandarina. The content its catalytic product, cis-vaccenic acid, was related expression levels Bmdesat5 strains. These two strains also showed significant differences intake. Using orally administering transgenic-mediated overexpression, verified functions as a satiation signal, regulating growth silkworms. Selection analysis experienced selection, especially potential promoter, 5′-untranslated, intron regions. This study highlights importance decrement satiety domestication provides new insights into involvement animals, by acting supplement gut-brain nutrient signaling.