Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1

• DOI: 10.1021/acs.jafc.4c02820
• Publication Date: 2024-05-31T16:50:38Z
• Authors: Bao-Jin Yi; Chi-Chiu Wang; Xiao-Wei Li; Ya-Ru Xu; Xiang-Yu Ma; Ping-An Jian; Milton Talukder; Xue-Nan Li; Jin-Long Li
• Keywords: Sting

Atrazine (ATR) is a widely used herbicide worldwide that can cause kidney damage in humans and animals by accumulation water soil. Lycopene (LYC), carotenoid with numerous biological activities, plays an important role protection due to its potent antioxidant anti-inflammatory effects. The current study sought investigate the of interactions between mtDNA cGAS-STING signaling pathway LYC mitigating PANoptosis inflammation kidneys induced ATR exposure. In our research, 350 mice were orally administered (5 mg/kg BW/day) (50 or 200 for 21 days. Our results reveal exposure induces decrease stability, resulting release into cytoplasm through mPTP pore BAX mobilization pathway, thereby inducing renal inflammation. inhibit above changes caused ATR. conclusion, inhibited exposure-induced histopathological changes, PANoptosis, inhibiting pathway. demonstrate positive ATR-induced injury provide new therapeutic target treating diseases clinic.