Comparative Study on the Antioxidative Effects and α-Glucosidase Inhibitory Potential In Vitro among Ellagic Acid and Its Metabolites Urolithins

• DOI: 10.1021/acs.jafc.4c06542
• Publication Date: 2024-11-20T13:18:52Z
• Authors: Zhao-Rong Li; Rui-Bo Jia; Yurong Mo; Haozheng Wang; Donghui Luo; Chunxia Zhou; Mouming Zhao
• Keywords: Ellagic Acid

The current study compared the radical scavenging and α-glucosidase inhibition potentials of ellagic acid (EA) its metabolites, urolithins (Uros), further explored structure-activity relationship. outcomes indicated that urolithin M5 (Uro-M5), EA, M6 (Uro-M6) exhibited superior 2,2-diphenyl-1-picrylhydrazyl (DPPH) activity; EA D (Uro-D) expressed better ABTS ability, Uro-M5 showed preferable activity. results CD spectra fluorescence spectral analysis explained interaction between Uros α-glucosidase. Correlation hydroxyl groups were crucial for antioxidative effect, while C-8 OH contributed greatly to Quantum mechanical both strong electrophilic properties. These comparative a biological discrepancy provided essential information exploring bioactive application as functional ingredient or dietary supplement.