Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice

• DOI: 10.1021/acs.jafc.5b01639
• Publication Date: 2015-07-26T14:21:23Z
• Authors: Hua Li; Hyeon-Seon Ji; Ji-Hyun Kang; Dong-Ha Shin; Ho-Yong Park; Myung-Sook Choi; Chul-Ho Lee; In-Kyung Lee; Bong-Sik Yun; Tae-Sook Jeong
• Keywords: Glucokinase; IRS1; FOXO1; IRS2

This study investigated the molecular mechanisms underlying antidiabetic effect of an ethanol extract soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas db/db-ESL group was ND with 1% ESL for 8 weeks. Dietary improved glucose tolerance lowered plasma glucose, glycated hemoglobin, HOMA-IR, triglyceride levels. The pancreatic insulin content significantly greater than that group. supplementation altered IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, FoxO1 expression. Furthermore, suppressed lipid accumulation increased glucokinase activity liver. primarily contained kaempferol glycosides pheophorbides. Kaempferol, aglycone glycosides, β-cell proliferation through IRS2-related signaling, pheophorbide a, product chlorophyll breakdown, secretion IRS1-related signaling protein kinase A MIN6 cells. effectively regulates homeostasis by enhancing IRS-mediated suppressing SREBP-1-mediated hepatic