Biochemical and Molecular Mechanisms of Radioprotective Effects of Naringenin, a Phytochemical from Citrus Fruits

• DOI: 10.1021/acs.jafc.5b05067
• Publication Date: 2016-02-16T17:10:49Z
• Authors: Sumit Kumar; Ashu Bhan Tiku
• Keywords: Male; Citrus; 0303 health sciences; Plant Extracts; Apoptosis; Radiation-Protective Agents; Antioxidants; 3. Good health; Mice; 03 medical and health sciences; Gamma Rays; Flavanones; Animals; Apoptosis Regulatory Proteins; Signal Transduction

The present study was aimed to evaluate the radioprotective effects of naringenin in vivo using Swiss albino mice as a model system. Oral administration 50 mg/kg body weight for 7 days prior radiation exposure protected against radiation-induced DNA, chromosomal and membrane damage. Naringenin pretreatment also increased antioxidant status irradiated mice. Multiple factors operating at cellular molecular levels led endogenous spleen colonies survival Although induces apoptosis cancer cells we found that it can protect normal by modulating expression p53, Bax, Bcl-2. results from indicate inhibits NF-kB pathway down regulates apoptotic proteins resulting radioprotection cellular, tissue organism levels.