Quercetin Alleviates Pyroptosis and Necroptosis Triggered on by DEHP Exposure in Bursa of Fabricius in Chicken by the ROS/MAPK/NF-κB Pathway

• DOI: 10.1021/acs.jafc.5c00224
• Publication Date: 2025-04-03T04:25:19Z
• Authors: Chenxi Huang; Xiaodan Wang; Wenwen Zhang; Meichen Liu; Ruirui Xie; Huiling Zheng; Xinyu Huo; Tong Xu; Hongjin Lin
• Keywords: Pyroptosis; Bursa of Fabricius

Bis(2-ethylhexyl) phthalate (DEHP) is an endocrine disruptor that may cause damage to several species. Quercetin (Que), a common flavonoid, has anti-inflammation, antioxidation, and immune regulation properties. In this study, we identified DEHP-exposed or Que-antagonist groups in chicken MSB-1 cells explore whether Que can mitigate DEHP-caused bursa of Fabricius pyroptosis necroptosis. The findings demonstrated reduced the expression necroptosis pyroptosis, inhibited mitogen-activated protein kinase (MAPK)/NF-κB pathway, mitigated oxidative stress caused by DEHP. addition reactive oxygen species activator (Sanguinarin) raised extent stress, NF-κB (nuclear factor-kappa-B activator1, act1) activated MAPK/NF-κB pathway compared + DEHP group. conclusion, counteract DEHP-induced programmed necrosis. This work adds toxicological consequences on avian further theoretical justification for Que's treatment organic toxic damage.