Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen

• DOI: 10.1021/acs.jafc.6b04145
• Publication Date: 2016-11-07T14:13:37Z
• Authors: Mengqi Wang; Yufei Xie; Youxiu Zhong; Juren Cen; Lei Wang; Yuanyuan Liu; Ying Zhu; Li Tong; Qun Wei
• Keywords: Inflammation; STAT3 Transcription Factor; 0303 health sciences; Encephalomyelitis, Autoimmune, Experimental; Plant Extracts; Terpenes; Macrophages; Anti-Inflammatory Agents; Cell Differentiation; Garcinia mangostana; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; STAT1 Transcription Factor; Spinal Cord; Animals; Th17 Cells; Female; Immunosuppressive Agents; Janus Kinases; Signal Transduction

Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice. The percentages of Th cells and macrophages were also strongly reduced. Isogarcinol appeared to act by inhibiting T helper (Th) 1 and Th17 cell differentiation via the janus kinase/signal transducers and activators of transcription pathway and by impairing macrophage function. Our data suggest that isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.