Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

• DOI: 10.1021/acs.jafc.7b06061
• Publication Date: 2018-03-05T08:28:04Z
• Authors: Pei Li; Deyu Hu; Dandan Xie; Jixiang Chen; Linhong Jin; Baoan Song
• Keywords: Moiety; Citrus canker; Xanthomonas citri; EC50; Oxadiazole; Xanthomonas; Ralstonia solanacearum

This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. ( Xoo) axonopodis citri Xac), the pathogens of rice bacterial leaf blight citrus canker, respectively, by performing turbidimeter tests. Antibacterial bioassay results showed that compound 6d revealed excellent bioactivities Xoo Xac, with 50% effective concentration (EC50) values 0.17 1.98 μg/mL, compared thiodiazole copper (121.82 77.04 respectively) bismerthiazol (92.61 58.21 respectively). Meanwhile, greenhouse-condition trials indicated that, bismerthiazol, more effectively reduced blight.