Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo

• DOI: 10.1021/acs.jafc.9b03847
• Publication Date: 2019-08-21T07:08:34Z
• Authors: Chang Liu; Yan Cui; Fuwei Pi; Yahui Guo; Yuliang Cheng; He Qian
• Keywords: Silibinin; ABTS

Torularhodin is a natural product extracted from Sporidiobolus pararoseus and has similar chemical structure to β-carotene. The antioxidative effects of torularhodin were investigated using DPPH, ABTS, cell oxidative damage model in vitro, d-galactose-induced liver-injured mouse vivo. Cell experiments demonstrated that had powerful effect on caused by H2O2 AML12 cells. significantly reduced inflammatory cytokines increased the activity antioxidant enzymes both serum liver. inhibition liver was correlated with torularhodin-mediated improving Nrf2/HO-1, reducing expression Bax NF-κB p65 western blot analysis. RT-PCR results upregulated mRNA Nrf2, NQO1, HO-1 In summary, scavenged free radicals prevented vitro oxidation via promotion Nrf2/HO-1 pathways