Bifenthrin Induces Fat Deposition by Improving Fatty Acid Uptake and Inhibiting Lipolysis in Mice

• DOI: 10.1021/acs.jafc.9b06727
• Publication Date: 2019-12-03T10:22:44Z
• Authors: Changsheng Wei; Xiaoting Wang; Xiangping Yao; Fengxue Xi; Yulin He; Yanting Xu; Lu Ma; Xiaochang Chen; Chen Zhao; Renrang Du; Weijun Pang; Gongshe Yang; Tai-yong Yu
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; Lipolysis; Fatty Acids; Lipase; Sterol Esterase; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; 3T3-L1 Cells; Pyrethrins; Adipocytes; Animals; Humans; Female; Obesity; Pesticides

Chemical residues in the environment are considered to be important factors that cause obesity. Bifenthrin is one of the pyrethroid pesticides and is widely used worldwide. However, its effect on adipose tissue is ill-defined. Here, we administered bifenthrin/corn oil to adult C57BL/6 mice by gavage. After 6 weeks, the bifenthrin treatment significantly increased their body weight (P = 0.015) and fat mass (P < 0.001). Then we identified 246 differently expressed proteins by proteomic analysis, and they were highly involved in fatty acid uptake and lipid metabolism processes. Interestingly, protein hormone-sensitive lipase and adipose triacylglyceride lipase were downregulated while lipoprotein lipase is upregulated after bifenthrin treatment. Similar effects in 3T3-L1 cells treated with bifenthrin validated the in vivo results. Thus, this study suggests that long-term exposure to low-dose bifenthrin induces fat deposition in mice by improving fatty acid uptake and inhibiting lipolysis, and it may cause obesity in humans.