Solubility Modeling and Solution Thermodynamics of 4-Amino-2,6-Dimethoxypyrimidine in Cosolvent Mixtures of Methanol, Ethanol, Isopropanol, and N,N-Dimethylformamide + Water

• DOI: 10.1021/acs.jced.8b00719
• Publication Date: 2018-10-22T19:45:25Z
• Authors: Renjie Xu; Chunjuan Huang
• Keywords: Mass fraction

The equilibrium solubility of 4-amino-2,6-dimethoxypyrimidine in different kinds binary mixed solvents—methanol + water (283.15–323.15 K), ethanol isopropanol and DMF K)—was measured by a dissolution technique under p = 101.1 kPa. experimental value has certain functional relationship with temperature the mass fraction methanol (ethanol, isopropanol, DMF). Within all fractions organic solvents temperature, was more soluble system than other three systems. Besides, calculated thermodynamic models, including Apelblat–Jouyban–Acree model, Jouyban–Acree van't Hoff–Jouyban–Acree to obtain maximum RAD (average relative deviations) 3.29%, which fully verified accuracy data.