Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras

• DOI: 10.1021/acs.jmedchem.4c02929
• Publication Date: 2025-03-31T16:41:49Z
• Authors: Charles W. Parry; Francesca Pellicano; Alexander W. Schü...; Kim S. Beyer; Justin Bower; Amy Bryson; Kenneth Cameron; Nichole M. Cerutti; Jonathan P. Clark; Stuart C. Davidson; Keneth Davies; Martin J. Drysdale; Jeffrey Engelman; Anna Estevan-Barber; Andrea Gohlke; Christopher H. Gray; Daniel A. Guthy; Min Hong; Alana Hopkins; Luke D. Hutchinson; Jennifer Konczal; Michel Maira; Duncan McArthur; Mokdad Mezna; Heather McKinnon; Ridvan Nepravishta; Nils Ostermann; Camila C. Pasquali; Katie Pollock; Angelo Pugliese; Nicholas Rooney; Niko Schmiedeberg; Paul Shaw; Camilo Velez-Vega; Christopher West; Ryan West; Frederic Zecri; John B. Taylor