Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

• DOI: 10.1021/acs.jnatprod.8b00321
• Publication Date: 2018-08-14T13:17:38Z
• Authors: Achara Raksat; Wisanu Maneerat; Raymond J. Andersen; Stephen G. Pyne; Surat Laphookhieo
• Keywords: Prenylation; Magnetic Resonance Spectroscopy; Bacteria; Molecular Structure; Plant Stems; Plant Extracts; Fabaceae; Microbial Sensitivity Tests; Gram-Positive Bacteria; Isoflavones; 01 natural sciences; Millettia; Anti-Bacterial Agents; 0104 chemical sciences; 3. Good health; Gram-Negative Bacteria

The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.