Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica

• DOI: 10.1021/acs.jnatprod.8b00683
• Publication Date: 2018-10-15T22:03:22Z
• Authors: Kevin Calabro; Bolivar E. Chalén; Grégory Genta-Jouve; Karla B. Jaramillo; Cristóbal Domínguez; Mercedes de la Cruz; Bastien Cautain; Fernando Reyes; Olivier P. Thomas; Jenny Rodríguez
• Keywords: Sponge; Moiety; Depsipeptide; IC50; Tropical Eastern Pacific

The first chemical study of the marine sponge Callyspongia cf. californica widely distributed along coasts Tropical Eastern Pacific led to identification a new family amphiphilic derivatives called callyspongidic acids. four isolated metabolites 1–4 feature hydrophilic diacid end opposed both an aromatic moiety and long alkyl chain. They were evaluated against panel pathogenic microbes seven tumoral cell lines, displaying moderate inhibitory properties A2058 melanoma line with IC50 3.2 μM for acid C13:0 (2).