Pd/C-Catalyzed Carbonylative Synthesis of α-Carbonyl-α′-Amide Sulfoxonium Ylides from Azides

• DOI: 10.1021/acs.joc.0c00273
• Publication Date: 2020-03-25T08:16:19Z
• Authors: Yang Yuan; Bo Chen; Youcan Zhang; Xiao-Feng Wu
• Keywords: Amide; Carbonylation

The synthesis of α-carbonyl-α′-amide sulfoxonium ylides by Pd/C-catalyzed carbonylative transformation azides with α-carbonyl has been studied. This method offers a direct approach to produce synthetically useful in high efficiency. By using readily available substrates, 39 examples products were prepared good yields outstanding functional group compatibility. An example converting the obtained ylide into corresponding 1,3-dicarbonyl compound given as well.