Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

• DOI: 10.1021/acs.joc.0c02827
• Publication Date: 2021-02-16T15:28:42Z
• Authors: Linwei Huang; Wei Liu; Liang-Liang Zhao; Zengyu Zhang; Xiaoyu Yan
• Keywords: Base (topology); Hydrogen–deuterium exchange; Reaction conditions; TRACE (psycholinguistics); Functional group

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional in medicinal chemistry. Herein, we investigated t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes DMSO-d6 solution. method provides excellent deuterium incorporation at the difluoromethyl group. Meanwhile, effect trace amount D2O solution on deuteration was also investigated.