A Noncoordinating Acid–Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols

• DOI: 10.1021/acs.joc.1c00193
• Publication Date: 2021-03-09T13:25:02Z
• Authors: Keith R. Fandrick; Nitinchandra D. P...; Suttipol Radomkit; Arindom Chatterjee; Stefan Braith; Daniel R. Fandrick; Carl A. Busacca; Chris H. Senanayake
• Keywords: Base (topology)

A mild and nonreversible tert-butylation of alcohols phenols can be achieved in high yields using the noncoordinating acid–base catalyst [bis(trifluoromethane)sulfonimide 2,6-lutidine] with a reagent, tert-butyl 2,2,2-trichloroacetimidate. This method allows use substrates containing acid sensitive groups such as ketal, Boc, boronate esters.