N-Trifluoromethoxyphthalimide: A Shelf-Stable Reagent for Nucleophilic Trifluoromethoxylation

• DOI: 10.1021/acs.joc.2c03031
• Publication Date: 2023-03-15T17:19:10Z
• Authors: Wen-Juan Yuan; Chao-Lai Tong; Xiu-Hua Xu; Feng-Ling Qing

Due to the unique properties of OCF3 group, trifluoromethyl ether compounds play an important role in pharmaceuticals and agrochemicals. Recently, considerable attention has been focused on development practical convenient reagents for direct incorporation group into organic compounds. Herein, we reported a new trifluoromethoxylating reagent N-trifluoromethoxyphthalimide (Phth-OCF3). The was stable solid released anion under mild reaction conditions. We demonstrated application Phth-OCF3 nucleophilic trifluoromethoxylation various alkyl electrophiles.