Nickel-Catalyzed Alkylation of Oxindoles with Secondary Alcohols

• DOI: 10.1021/acs.joc.3c00402
• Publication Date: 2023-05-10T22:50:51Z
• Authors: Atanu Bera; Adrija Ghosh; Debasis Banerjee

Herein, we have demonstrated a simple nickel-catalyzed C-3-selective alkylation of 2-oxindoles using a wide variety of secondary alkyl alcohols. As a special highlight, functionalization of the cholesterol derivative was reported. Control experiments, initial mechanistic studies, and deuterium-labeling experiments were performed for the alkylation process.