NaOAc-Assisted Aerobic Oxidation Protocol for the Synthesis of Pentacoordinate Chalcogenyl Spirophosphoranes with P–Se/P–S Bonds under Open Air

• DOI: 10.1021/acs.joc.3c02716
• Publication Date: 2024-02-21T12:16:46Z
• Authors: Yang Zhang; Yanchun Guo; Yufen Zhao; Shuxia Cao
• Keywords: Chalcogen; Functional group

The NaOAc-assisted aerobic oxidation reaction of pentacoordinate hydrospirophosphoranes and dichalcogenyl compounds with open air as a green oxidant has been developed under mild conditions. A series novel spirophosphoranes P–Se/P–S bonds were synthesized in excellent yields. mechanism was determined by 31P nuclear magnetic resonance tracing experiments, high-resolution mass spectrometry X-ray diffraction analysis. method features broad substrate scope, good functional group tolerance, high degree atomic utilization is meaningful for the synthesis bioactive chalcogenphosphate chalcogen phosphorus moieties.