Formation of Substituted Benzocyclobutenes Starting from Donor–Acceptor Cyclopropanes

• DOI: 10.1021/acs.joc.4c02926
• Publication Date: 2025-03-06T20:45:01Z
• Authors: Bohdan Biletskyi; Maxime Dousset; Pierre Colonna; Virginie Héran; Yannick Carissan; Laurent Commeiras; Gaëlle Chouraqui
• Keywords: Benzocyclobutene; Cyclopropane; Acceptor; Reactivity

We describe an operationally simple, good-yielding, two-step cascade process to convert biscyclopropanes 1 into high-value benzocyclobutene building blocks 3. This study highlights the novel reactivity of our "in-house" donor-acceptor cyclopropane, achieving complete diastereoselectivity and regioselectivity transfer.