The Reactivity of Thymine and Thymidine 5,6-Epoxides with Organometallic Reagents – A Route to Thymidine (6-4) Photoproduct Analogues

• DOI: 10.1021/acs.joc.6b00495
• Publication Date: 2016-04-15T09:28:15Z
• Authors: Pauli Wrigstedt; Jari Kavakka; Sami Heikkinen; Martin Nieger; Minna Räisänen; Timo Repo
• Keywords: Boron Compounds; Alcohols; Organometallic Compounds; Epoxy Compounds; Stereoisomerism; DNA; 01 natural sciences; Thymine; Thymidine; 0104 chemical sciences; 3. Good health

AbstractThe formation of thymine and thymidine 5,6‐epoxides from the corresponding trans‐5,6‐bromohydrins and their in‐situ reaction with a broad range of organometallic reagents is examined.