Methylenecyclopropane Ring Formation/Opening Cascade for the Synthesis of Indolizines

• DOI: 10.1021/acs.joc.7b01073
• Publication Date: 2017-06-01T09:15:36Z
• Authors: Congjun Zhu; Peng Zhao; Yan Qiao; Ke Xiao; Chuanjun Song; Junbiao Chang
• Keywords: Methylenecyclopropane; Structural isomer

A unique strategy toward the synthesis of polysubstituted indolizines has been developed. When 2-pyridinyl-2-(2'-bromoallyl)-1-carboxylates were treated with Cs2CO3, starting material went through a methylenecyclopropane ring formation/opening cascade, and corresponding obtained in moderate to good yield as single regioisomer.