A Convergent Approach to Diverse Spiroethers through Stereoselective Trapping of Rhodium Carbenoids with Gold-Activated Alkynols

• DOI: 10.1021/acs.joc.7b03196
• Publication Date: 2018-01-31T17:24:38Z
• Authors: Arianne C. Hunter; Steven C. Schlitzer; Joseph C. Stevens; Bilal Almutwalli; Indrajeet Sharma
• Keywords: Convergent synthesis; Reactivity

A convergent approach for the stereoselective synthesis of diverse spiroethers is described. The reaction involves trapping diazo-derived rhodium carbenoids with gold-activated alkynols installation spiro cores. has proven general a range readily accessible homopropargylic alcohols and diazo carbonyls to provide functionalized spiroether cores bioactive scaffolds such as spirobarbiturates, spirooxindoles, pseurotin natural products.