Transition-Metal-Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines

• DOI: 10.1021/acs.joc.8b01204
• Publication Date: 2018-07-03T16:29:48Z
• Authors: Mandalaparthi Pha...; Sandip Balasaheb ...; Dipak Kumar Tiwari; Pravin R. Likhar; Dharmendra Kumar ...
• Keywords: Atom economy; Carbon atom

An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines alkynes in presence K2S2O8 DMSO has been developed. A variety having a diverse range substitution patterns can undergo one-pot cascade process successfully. Effectively, this method uses as one carbon source, thus providing highly atom-economical environmentally benign 4-arylquinolines.