Copper-Catalyzed Perfluoroalkylation of Allyl Phosphates with Stable Perfluoroalkylzinc Reagents

• DOI: 10.1021/acs.joc.8b02432
• Publication Date: 2018-12-07T10:05:41Z
• Authors: Lihua Liu; Xifei Bao; Hua Xiao; Junlan Li; Feifan Ye; Chaoqin Wang; Qinhua Cai; Shilu Fan
• Keywords: Catalytic cycle; Functional group

A general and practical method for copper-catalyzed cross-coupling of allyl phosphates with stable perfluoroalkylzinc reagents has been developed. The reaction proceeds under mild conditions high efficiency, good functional group tolerance, regio- stereoselectivities provides general, straightforward, useful access to allyl-perfluoroalkyl compounds. Preliminary mechanistic studies reveal that the copper intermediate may be involved in catalytic cycle.