Visible-Light-Catalyzed [3 + 1 + 2] Coupling Annulations for the Synthesis of Unsymmetrical Trisubstituted Amino-1,3,5-triazines

• DOI: 10.1021/acs.joc.9b02514
• Publication Date: 2019-11-01T08:13:01Z
• Authors: Wei Guo; Mingming Zhao; Chengtang Du; Lvyin Zheng; Luo Li; Liping Chen; Kailiang Tao; Wen Tan; Zhen Xie; Liuhuan Cai; Xiaolin Fan; Kai Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

A visible-light catalyzed [3 + 1 + 2] annulation for the synthesis of unsymmetrical trisubstituted amino-1,3,5-triazines from amidines, isothiocyanates, and 1,1,3,3-tetramethylguanidines has been developed. This method exhibits the advantages of easily available starting materials, insensitive to air and moisture, wide substrate scopes, high step economy, mild, metal- and ligand-free conditions, which has potential applications in the organic, medicinal, and material chemistry.