Selective Entropy Gain-Driven Adsorption of Nanospheres onto Spherical Bacteria Endows Photodynamic Treatment with Narrow-Spectrum Activity

• DOI: 10.1021/acs.jpclett.0c00287
• Publication Date: 2020-03-19T18:59:31Z
• Authors: Binqian Yang; Feng Gao; Zhiyuan Li; Mingyang Li; Liang Chen; Yong Guan; Gang Liu; Lihua Yang
• Keywords: 0301 basic medicine; 03 medical and health sciences; Photochemotherapy; Entropy; Adsorption; Gram-Positive Bacteria; Nanospheres

Narrow-spectrum antimicrobials specifically eradicate the target pathogens but suffer from significantly lagging development. Photodynamic therapy eliminates cells with reactive oxygen species (ROS) generated upon light irradiation is intrinsically a wide-spectrum modality. We herein converted photodynamic into narrow-spectrum modality by taking advantage of previously unnoticed physics recognition pathway. found that negatively charged nanospheres undergo selective entropy gain-driven adsorption onto spherical bacteria, not rod-like bacteria. This bacterial morphology-targeting selectivity, combined extremely limited effective radii action ROS, enabled to kill >99% inoculated bacteria and <1% under comparable conditions, indicative activity against work unveils morphology selectivity in suggests new approach for treating infections characterized overthriving niches naturally dominated