Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

• DOI: 10.1021/acs.jpclett.7b01512
• Publication Date: 2017-07-14T16:45:40Z
• Authors: Jean-Nicolas Dumez; Basile Vuichoud; Daniele Mammoli; Aurélien Bornet; Arthur C. Pinon; Gabriele Stevanato; Benno Meier; Geoffrey Bodenhausen; Sami Jannin; Malcolm H. Levitt
• Keywords: [CHIM.ANAL] Chemical Sciences/Analytical chemistry; [CHIM.ANAL]Chemical Sciences/Analytical chemistry; 540; 01 natural sciences; 0104 chemical sciences

We have induced hyperpolarized long-lived states in compounds containing 13C-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed dissolution with a warm solvent. The give rise to enhanced antiphase 13C NMR signals solution, which often persist for times much longer than the and 1H spin–lattice relaxation under same conditions. DNP-induced effects are similar quantum-rotor-induced (QRIP) but observed wider range of because they do not depend critically on height rotational barrier. interpret our observations model Zeeman tunnelling reservoirs adopt an approximately uniform temperature, DNP generation that relatively long methyl-bearing substances may be important applications such as investigations metabolism, enzymatic reactions, protein–ligand binding, drug screening, molecular imaging.