Tissue Lipidomic Alterations Induced by Prolonged Dexamethasone Treatment

• DOI: 10.1021/acs.jproteome.0c00759
• Publication Date: 2021-02-09T08:00:50Z
• Authors: Adriana Zardini B...; Abeer Malkawi; Essa M. Sabi; Ahmed H. Mujamammi; Liang Li; Anas M. Abdel Rahman
• Keywords: Muscle disorder

Dexamethasone is a synthetic glucocorticoid medication vastly used to treat abnormal immune responses and inflammation. Although the well-established in medical community, prolonged treatment with high dosages of dexamethasone may lead severe adverse effects through mechanisms that are not yet well-known. Lipids large class hydrophobic molecules involved energy storage, signaling, modulation gene expression, membranes. Hence, untargeted lipidomics help unravel biochemical alterations following dexamethasone. We performed comprehensive lipidomic analyses brain, heart, kidney, liver, muscle samples obtained from rats were treated intramuscular injections for 14 weeks compared healthy controls. The employed methodology statistical analysis showed phosphatidic acids, glycerophospholipids, plasmalogens, fatty acids deeply affected by use medication. Brain tissue was only mildly affected, but skeletal strong accumulation lipids be correlated metabolism, myopathy, oxidative processes. This work provides new insights into action one most commonly prescribed drugs world.