Amniotic Fluid and Maternal Serum Metabolic Signatures in the Second Trimester Associated with Preterm Delivery

• DOI: 10.1021/acs.jproteome.6b00845
• Publication Date: 2017-01-09T10:22:32Z
• Authors: Christina Virgiliou; Helen G. Gika; Michael Witting; Anna A. Bletsou; Apostolos Athanas...; Menelaos Zafrakas; Nikolaos S. Thoma...; Nikolaos Raikos; Georgios Makrydimas; Georgios A. Theod...
• Keywords: Second trimester; Metabolome

Preterm delivery (PTD) represents a major health problem that occurs in 1 10 births. The hypothesis of the present study was metabolic profile different biological fluids, obtained from pregnant women during second trimester gestation, could allow useful correlations with pregnancy outcome. Holistic and targeted metabolomics approaches were applied for complementary assessment content prospectively collected amniotic fluid (AF) paired maternal blood serum samples 35 who delivered preterm (between 29 weeks + 0 days 36 +5 gestation) at term. results revealed trends relating analyzed delivery. Untargeted profiling showed differentiations certain key metabolites fluids two groups. In AF, intermediate involved energy metabolism (pyruvic acid, glutamic glutamine) found to contribute classification serum, increased levels lipids alterations end-point observed cases Overall, second-trimester AF shows potential identification biomarkers related fetal growth