Coronary Stents Decorated by Heparin/NONOate Nanoparticles for Anticoagulant and Endothelialized Effects

• DOI: 10.1021/acs.langmuir.0c00112
• Publication Date: 2020-02-29T20:20:57Z
• Authors: Tianyu Zhu; Min Zhou; Wentao Gao; Dan Fang; Zhiyong Liu; Guangyan Wu; Mimi Wan; Chun Mao; Jian Shen
• Keywords: Thrombogenicity; Coronary stent

In the treatment of coronary artery disease (CAD), use stent implantation often leads to clinical complications such as restenosis, delayed endothelial healing, and thrombosis. Here, we develop a double drug sustained-release coating for surface by grafting heparin/NONOate nanoparticles (Hep/NONOates). The Hep/NONOates modification were characterized X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared static water contact angle, scanning electron microscopy (SEM), release behaviors anticoagulant, heparin (Hep) bioactive molecule, nitric oxide (NO) studied. Furthermore, blood compatibility cytotoxicity modified evaluated whole adhesion platelet tests, hemolysis assay, morphological changes red cells, plasma recalcification time in vitro coagulation MTT assay. Finally, results rabbit carotid experiment showed that can accelerate regeneration cells keep good anticoagulant activity. This study provide new design ideas based on nanotechnology improving safety effectiveness drug-eluting stents.