Highly Hydrophilic Luminescent Magnetic Mesoporous Carbon Nanospheres for Controlled Release of Anticancer Drug and Multimodal Imaging

• DOI: 10.1021/acs.langmuir.5b03898
• Publication Date: 2016-01-21T21:24:59Z
• Authors: Sasmita Mohapatra; Smruti R. Rout; Rahul K. Das; Santoshi Nayak; Sudip K. Ghosh
• Keywords: Anticancer drug; Carbon fibers

Judicious combination of fluorescence and magnetic properties along with ample drug loading capacity control release property remains a key challenge in the design nanotheranostic agents. This paper reports synthesis highly hydrophilic optically traceable mesoporous carbon nanospheres which can sustain payloads anticancer doxorubicin T2 contrast agent such as cobalt ferrite nanoparticles. The luminescent hybrid system has been prepared on silica template using resorcinol-formaldehyde precursor. matrix shows controlled aromatic due to disruption supramolecular π–π interaction at acidic pH. particles show MR behavior by affecting proton relaxation transverse relaxivity (r2) 380 mM–1 S–1. multicolored emission upconversion luminescence our sample are advantageous bioimaging. In vitro cell experiments that nanoparticles endocyted tumor cells through passive targeting. pH-responsive presents chemotherapeutic inhibition growth induction apoptosis.