Antimicrobial Effect of Biocompatible Silicon Nanoparticles Activated Using Therapeutic Ultrasound

• DOI: 10.1021/acs.langmuir.6b04303
• Publication Date: 2017-02-17T14:55:01Z
• Authors: Svetlana N. Shevc...; Markus Burkhardt; Eugene V. Sheval; Ulyana A. Natashina; Christina Grosse; Alexander L. Niko...; Alexander V. Gopin; Ute Neugebauer; Andrew A. Kudryav...; Vladimir Sivakov; Liubov A. Osminkina
• Keywords: Biopolymer

In this study, we report a method for the suppression of Escherichia coli (E. coli) vitality by means therapeutic ultrasound irradiation (USI) using biocompatible silicon nanoparticles as cavitation sensitizers. Silicon without (SiNPs) and with polysaccharide (dextran) coating (DSiNPs) were used. Both types nontoxic to Hep 2 cells up concentration mg/mL. The treatment bacteria application 1 W/cm2 USI resulted in reduction their viabilities 35 72% SiNPs DSiNPs, respectively. higher bacterial viability DSiNPs compared can be explained fact that biopolymer shell provides stronger adhesion surface. Transmission electron microscopy (TEM) studies showed lipid was partially perforated after combined USI, which lysis membrane due sensitized SiNPs. Furthermore, have shown 100% inhibition E. colony growth is possible coupling treatments an increased intensity 3 W/cm2. observed results reveal promising antimicrobial agents.