Self-Assembled Lipid Cubic Phase and Cubosomes for the Delivery of Aspirin as a Model Drug

• DOI: 10.1021/acs.langmuir.7b02486
• Publication Date: 2017-08-22T02:49:02Z
• Authors: Chandrashekhar V....; Vinod Kumar Vishw...; Abraham Quarshie; Zeinab Moinuddin; James Page; Pravin Kendrekar; Samson S. Mashele
• Keywords: Nanocarriers; Small-angle X-ray scattering

Three-dimensionally organized lipid cubic self-assemblies and derived oil-in-water emulsions called "cubosomes" are attractive for various biotechnological applications due to their ability be loaded with functional molecules associated sustained release properties. Here, we employed both of these lipid-based systems the delivery a model drug, aspirin, under comparable conditions. Studies were performed by varying drug-to-lipid ratio type medium, water phosphate buffer saline (PBS). Release rates determined using UV–vis spectroscopy, small-angle X-ray scattering was used confirm self-assembled nanostructures formed in systems. The from bulk phase as compared that dispersed cubosomes, PBS more efficient than water. tortuosity architecture, length diffusion pathway, nanostructure, physicochemical interaction media evidently contribute observations. This work is particularly important it first report where nanostructured have been studied together similar provides insights into understanding therefore controlling behavior drug nanocarriers.