Stability of Polyethylene Glycol and Zwitterionic Surface Modifications in PDMS Microfluidic Flow Chambers

• DOI: 10.1021/acs.langmuir.7b03095
• Publication Date: 2017-12-12T19:23:08Z
• Authors: Thomas J. Plegue; Kyle M. Kovach; Alex J. Thompson; Joseph A. Potkay
• Keywords: Platelet Adhesiveness; Surface Properties; Lab-On-A-Chip Devices; Adsorption; Dimethylpolysiloxanes; 02 engineering and technology; Silanes; 0210 nano-technology; Hydrophobic and Hydrophilic Interactions; Polyethylene Glycols

Blood–material interactions are crucial to the lifetime, safety, and overall success of blood contacting devices. Hydrophilic polymer coatings have been employed improve device lifetime by shielding materials from natural foreign body response, primarily intrinsic pathway coagulation cascade. These ability repel proteins, cells, bacteria, other micro-organisms. Coatings desired long-term stability, so that nonthrombogenic nonfouling effects gained long lasting. Unfortunately, there exist limited studies which investigate their stability under dynamic flow conditions as encountered in a physiological setting. In addition, direct comparisons between multiple lacking literature. this study, we polyethylene glycol (PEG), zwitterionic sulfobetaine silane (SBSi), (PEG-SBSi) grafted room temperature, sequential chemistry process on polydimethylsiloxane (PDMS) over time ambient, static fluid (no flow), physiologically relevant compare results uncoated PDMS controls. PEG, SBSi, PEG-SBSi maintained contact angles below 20° for up 35 days ambient conditions. SBSi showed increased hydrophilicity after 7 They also retained ≤40° all shear rates flow, demonstrating potential stability. The effectiveness resist platelet adhesion was studied PEG 69% reduction adhered platelets, significant 80% reduction, 96% compared control samples, applicability applications. presented may be interest applications including marine coatings, lab chip devices, lenses, where it is desirable reduce surface fouling due organisms.